Trying to read too deeply into Wilfred is riddled with problems (mainly because it could be a show like Children's Hospital where random, funny shit just happens), but "Compassion" comes out and tells us that Ryan's problems are genetic. Ryan's mother is crazy herself and at the end of the episode, we see her cat who is a person in a cat outfit. My interpretation: the writers are telling us that Ryan won't solve his psychological problems through the course of the show. And if this is the case, I won't mind. Ryan's mother, played by Mary Steenburgen, and Wilfred were both very funny and I'll keep coming as long I think it's funny.
Score: 9.0/10